what is 5-Amino-1MQ?
5-amino-1MQ is a small molecule that inhibits the activity of the enzyme called nicotinamide N-methyltransferase (NNMT). NNMT plays a crucial role in metabolism and energy, primarily in fat tissue. By blocking NNMT, 5-amino-1MQ promotes an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor essential for cellular metabolism. This, in turn, boosts metabolic rate and activates a gene known as sirtuin-1 (SIRT1), also referred to as the "longevity gene." SIRT1 is involved in reducing the risk of various conditions such as diabetes, obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer.