retatrutide weight loss program

what is peptide weight loss with retatrutide?

Retatrutide is a new medication for diabetes and weight loss, with potential cardiovascular benefits. It shows promise as the best weight loss medication compared to popular options like semaglutide and tirzepatide.

The medication is based on a modified version of a peptide called GIP. This modification allows retatrutide to bind to a protein called albumin in the blood, keeping it in the bloodstream for a long time. As a result, people only need to take it once a week. Retatrutide works on three different receptors in the body: GCGR, GIPR, and GLP-1R. This threefold activity has been linked to significant weight loss (up to 25% of body weight in 48 weeks) in clinical trials. This makes retatrutide the most effective among incretin peptides tested so far.

How does weight loss with retatrutide work?

Research in humans shows that retatrutide activates all three incretin receptors: GIP, GLP-1, and GCG, to their full extent. Retatrutide is very powerful at the GIP and GLP-1 sites, making it one of the strongest incretins. It affects both stomach emptying and how our brains control hunger and fullness.
Most of retatrutide’s effects come from reducing fat mass, likely because it helps people eat less for longer periods compared to similar medications. Eating less, especially at the beginning of using retatrutide, starts burning fat. This aids long-term weight loss by changing how our bodies use energy and fighting against the hormones that cause obesity.
While retatrutide mainly works by reducing food intake, it also increases energy expenditure, which is important for weight loss.

Retatrutide effects on each receptor

GIP Effect: Stimulating GIP reduces stomach acid and a hormone called gastrin, which helps digest food. Slowing down digestion makes us feel fuller.

GLP-1 Effects: Activating the GLP-1 receptor delays stomach emptying, supported by research in both animals and humans. Slower stomach emptying affects how our bodies handle blood sugar after eating. This can help us eat less and lose weight.

GCG Effects: Recent research shows that glucagon, which acts through the GCG receptor, helps control hunger and how our bodies use energy. Glucagon signals the brain from the gut through the vagal nerve, making us feel full. Glucagon levels in the liver’s portal circulation regulate this signaling. Studies show that giving glucagon leads to a 20% weight loss and increases energy use. However, this effect isn’t directly through the GCG receptor but through another protein called FGF21, which is secreted by the liver. FGF21 helps burn fat without changing how much we eat.

• Significant potential for weight loss
• Once-weekly injection
• Improve blood pressure
• Prevent your liver from making too much sugar
• The pancreas produce more insulin when your blood sugar levels are high
• Control blood glucose
• Reduce hyperglycemia, especially after meals
• Reduce fasting insulin and fasting glucose
• Reduce hemoglobin A1c
• Decrease appetite and caloric intake, while inhibiting weight gain
• Lower triglyceride levels and oxidative stress from high LDL
• Decrease leptin and increase leptin sensitivity
• Increase the conversion of white fat to brown fat

the biostation's 8-12 week retatrutide peptide weight loss program includes:

The biostation's retatrutide program includes an intake session and a blood panel to establish your eligibility. The program then starts with the administration of retatrutide by injection. You will be given a weight reduction protocol and healthy weight management plan, which is devised and monitored by a doctor, with weekly monitoring based on your personal weight loss goals. The following elements are also included with our retatrutide peptide weight-reduction program to ensure the finest outcomes for our patients:

• Intake session and comprehensive blood panel to confirm that you are a candidate for the program
• Doctor designed and supervised weight loss protocol and healthy weight management plan with weekly monitoring, based on your personalized weight loss needs
• Perform InBody testing and monitoring twice a month to track progress.
• bEssential 7-Day Metabolic Detox
• The Blueprint Nutrition Manual
• A Guide To Intermittent Fasting
• Patient Advocate support
• Root cause analysis
• Retatrutide application method: injection