How does Tirzepatide a GLP-1/GIP peptide work for weight loss?
Tirzepatide is unique because it is the first medication that combines two classes of medication: a glucagon-like peptide-1 (GLP-1) receptor agonist and a glucose-dependent insulinotropic polypeptide (GIP) receptor agonist. This makes it a dual GLP-1/GIP receptor agonist. Together, these functions can help reduce hunger and lose more weight.
Tirzepatide binds to a receptor of two hormones generated in the gut termed glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). It works in the same manner as GIP and GLP-1 by increasing the amount of insulin the pancreas releases in response to meals, encouraging healthy blood glucose regulation.
How Can Tirzepatide Aid in Weight Loss?
As a dual glucose-dependent insulinotropic polypeptide GIP and GLP-1 agonist, tirzepatide has been shown in clinical studies to aid in weight reduction. Tirzepatide produces its weight loss results through the following mechanisms of action:
Tirzepatide affects the brain's appetite-regulating centers, resulting in less hunger and a longer sense of fullness.
Slowed Gastric Emptying
Tirzepatide delays stomach emptying, which might cause food to take longer to travel through the digestive system. This delay in stomach emptying can also promote satiety and aid in food intake management.
Improved Insulin Sensitivity
Tirzepatide enhances insulin sensitivity, which means that the cells in the body are more sensitive to the actions of insulin. Increased insulin sensitivity can improve glucose absorption by cells while decreasing glucose synthesis by the liver. This kind of healthy blood sugar regulation is important for weight loss.
Increased Energy Expenditure
Tirzepatide has been linked to an increase in increased physical activity. Weight loss is inevitable if the body burns more calories than the caloric intake.
Tirzepatide has been proven to increase fat cell breakdown, also known as lipolysis. Releasing stored fat to produce energy is fundamental for weight loss.
It's crucial to note that the weight reduction benefits of tirzepatide vary from person to person, and researchers have mostly examined it in type 2 diabetes patients specifically. Individuals may have different processes and proportional contributions to weight reduction.
Tirzepatide peptide can also help:
- Release insulin when blood sugar is high
- Remove excess sugar from the blood
- Prevent the liver from producing and releasing an excessive amount of sugar.
- Slow down food digestion
- Achieve significant weight loss
- Lower BMI and accelerates fat loss
- Reduce inflammation promote gut health
- Lower A1C
- Cardiovascular benefits - lower risks of cardio events
- Control food cravings