Human growth hormone is naturally produced in the pituitary gland and plays a vital role in the growth of every cell in the human body, cell regeneration, maintaining healthy tissue throughout the body, and keeping your body functioning at peak performance.
Growth hormone is released in bursts every three to five hours by the pituitary gland. The hypothalamus in the brain regulates the secretion of hormones from the pituitary gland. In order for the pituitary gland to release more growth hormone, the hypothalamus must release growth hormone-releasing hormone (GHRH). The GHRH in turn signals the pituitary gland to release growth hormone.
As we age, the pituitary gland simply does not produce as much HGH, and our levels naturally decline. In women, HGH levels start to decline in the early 20s. In men, it is usually around age 35. In middle age, HGH levels are usually less than half of what they were in a person’s early 20s. As our HGH levels decrease, we start to notice negative effects like weight gain, muscle loss, decreased energy levels, reduced strength and stamina, low libido or sexual dysfunction, poor sleep and aging skin.
If you are feeling the effects of aging mentioned above, you should have your levels checked by a Functional Medicine expert to determine if you have adult growth hormone deficiency. You could be a candidate for hormone replacement therapy. At the biostation, our hormone therapy options for treating growth hormone deficiency include Sermorelin and Ipamorelin, which are both bioidentical growth hormone-releasing hormones known to be safer and more effective than synthetic HGH replacement therapy.
Sermorelin Acetate is a bioidentical hormone therapy medication that has been used to treat Human Growth Hormone (HGH) deficiency since the 1970’s. This powerful peptide is composed of 29 amino acids and functions by stimulating your pituitary gland so it can produce its own human growth hormone. Sermorelin is a Growth Hormone Releasing Hormone. It differs from synthetic HGH replacement therapy, which seeks to directly replace HGH in the body. The effects of Sermorelin are regulated by the pituitary gland from the release of somatostatin (a growth inhibiting hormone that indicates high levels of HGH), so that overdose of HGH is difficult if not impossible.
Sermorelin is a self-injectable treatment that can aid the production of HGH in the body during the sleep cycle. This results in a feeling of bodily rejuvenation upon waking, instead of the tiredness that never seems to go away as we age.
Sermorelin Injections are administered via a method known as Subcutaneous Injection, or as SubQ Injection. Subcutaneous Injections are delivered using a short, thin needle known as an insulin needle, and the needle is injected just underneath the skin in the subdermal layer. Generally, these injections are delivered into the stomach or hip. Sermorelin Injections are administered once daily, generally five days per week.
Sermorelin may be used safely in conjunction with bioidentical hormone replacement therapy,, weight loss programs, and erectile dysfunction treatment. Sermorelin is one of our most popular anti-aging medications for patients who struggle with the effects of sub-optimal HGH levels.
Called the “gold standard” of age management therapy, Ipamorelin Acetate is one of the safest, most effective forms of growth hormone restoration. This 3rd generation HGH therapy has no reported negative side effects or adverse reactions. Ipamorelin has shown to be one of the longer lasting, extremely effective forms of HGH therapies to treat Adult Growth Hormone Deficiency. This treatment’s function is a slow building one which mimics the body’s natural growth hormone release.
Ipamorelin is a pentipeptide, meaning that it is composed of five amino acids. Like Sermorelin, this bioidentical therapy is a growth hormone releasing hormone, meaning that it stimulates the pituitary gland to mimic the natural growth hormone (GH) pulses of the body, and provides a slow and steady release of GH. It is extremely stable in suppressing somatostatin.
Ipamorelin has no reported negative side effects, including no reported spikes in cortisol or prolactin levels. Patients report no hunger side effects as experienced with other GH therapies. Because there are no adverse reactions or negative side effects, your doctor is able to prescribe Ipamorelin more aggressively and more frequently than other therapies without the risk of elevated cortisol and acetylcholine blood plasma levels. This helps keep your HGH level optimized for a longer period of time, which ultimately leads to higher patient success.
Ipamorelin can be administered in two ways: Troche form (a small lozenge that dissolves under the tongue), and Subcutaneous Injection (or SubQ Injection). Ipamorelin in Troche form is placed under the tongue and absorbs directly into the bloodstream. This application method bypasses the stomach and first-pass metabolism of the liver, and is absorbed directly into the buccal circulation. Troche form offers the highest absorption rate. SubQ Injections are delivered just under the skin in the subdermal layer using an insulin needle. Ipamorelin injections are administered once daily, generally five days per week.
Ibutamoren Acetate is classified as a non-peptide growth hormone secretagogue, which means it stimulates the pituitary gland to release stored growth hormone to the body for use. By using growth hormone secretors, the body increases production of its own growth hormone. As a result, the body repairs and rejuvenates itself over time, which slows down the aging process. Peptide therapies usually have a “loading” period of 3-6 months before full effects are noticed and can be used indefinitely with little to no side-effects for long-term use.
Ibutamoren remains active in the body for a longer period of time compared to injectable secretagoues, GHRP 2 or GHRP 6. Ibutamoren requires only a once daily orally administered dose at bedtime and remains active for roughly 24 hours in the body.
Like other forms of Hormone Replacement Therapy, Sermorelin and Ipamorelin take time to work in order for the full array of benefits to manifest themselves. In the first weeks of therapy patients generally report changes in energy levels and improved sleeping habits and mood, but physical changes can take three to six months to become apparent. After six months, most patients will start to show significant benefits in body composition, skin health, immune health, and healing response.